Presence of Fleischer ring and prominent corneal nerves in keratoconus relatives and normal controls.

نویسندگان

  • Ágnes Kriszt
  • Gergely Losonczy
  • András Berta
  • Lili Takács
چکیده

AIM To examine the occurrence of commonly known clinical signs of keratoconus (KC), i.e. Fleischer ring, prominent corneal nerves and thinning, among unaffected family members of KC patients and healthy control individuals. METHODS Data of both eyes of 117 relatives of KC patients having no manifest disease based on videokeratography indices (KC relatives), and 142 controls were used for Pearson correlation and t-test statistics. Correlation of Fleischer ring, prominent corneal nerves and central pachymetry data were tested with each other and with videokeratography indices (KSI, KISA, 3 and 6 mm Fourier asymmetry, and I-S). RESULTS A moderate correlation was found between Fleischer ring and all examined topographical indices. Most important correlation was present with 6 mm Fourier asymmetry, and corneal pachymetry (r=0.272, P<0.001; r=-0.234, P=0.027, respectively). Similar correlations were found with prominent corneal nerves (r=0.234, P<0.001 for 6 mm Fourier asymmetry and r=-0.235, P=0.0265 for pachymetry). KC family members who exhibited Fleischer ring or prominent nerves had thinner and more asymmetric corneas than those without Fleischer ring or prominent corneal nerves (P<0.05 for pachymetry and topographic indices with t-test and Mann-Whitney rank sum test). Though rarely, Fleischer ring and prominent corneal nerves occurred among normal controls, indicating the existence of forme fruste cases in the normal population. Control subjects, who had corneal Fleischer ring or prominent nerves had corneas more similar to KC than other controls (t-test: increased KSI and KISA, P=0.048 and 0.012, respectively). CONCLUSION In KC family members and healthy individuals, Fleischer ring and prominent corneal nerves are associated with features of KC and may suggest a possibility of forme fruste KC. Searching for the possible presence of Fleischer ring or prominent nerves on the cornea may help in the decision whether or not to diagnose subclinical KC in a borderline case.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

ویژگی‌های بیومکانیکی قرنیه در بیماران مبتلا به کراتوکونوس و ارتباط آن با شدت بیماری

Background and Objective: Keratoconus is a disorder in cornea characterized by constant thinning and prominence that can result in vision defect. Due to ultrasonic changes in the corneal structure caused by keratoconus disease, its rigidity and biomechanical properties are subject to some changes. In this regard, the present study was conducted to determine the correlation of biomechanical feat...

متن کامل

Prediction of Corneal Condition After Corneal Ring Implantation in Keratoconus Patients

Background: Keratoconus is a common complication among corneal defects. As a result of expeditious and extensive progress of medical science in recent decades, corneal ring implantation has turned into a successful surgical procedure to correct the vision of Keratoconus patients; however, selecting the right patient is essential in the success of the operation. The prediction of corneal conditi...

متن کامل

Secondary keratoconus with corneal epithelial iron ring similar to Fleischer's ring.

BACKGROUND Fleischer's ring is considered to be a characteristic of keratoconus, but we have seen a ring similar to Fleischer's ring in patients with secondary keratoconus, in which the cornea becomes thinner secondarily for undetermined reasons. CASES We report 6 cases of secondary keratoconus with a corneal epithelial ring similar to the Fleischer's ring pattern. OBSERVATIONS In these 6 c...

متن کامل

Comparison of stromal corneal nerves between normal and keratoconus patients using confocal microscopy.

OBJECTIVE To evaluate the differences in stromal corneal nerves between normal patients and keratoconus patients. MATERIAL AND METHODS A total of 140 eyes of 70 normal patients (group A) and 122 eyes of 87 keratoconus patients (group B) were examined with the confocal microscope, with a central scan of the total corneal thickness being taken. The morphology and thickness of the corneal stroma...

متن کامل

Fusion of Different Corneal Parameters to Improve the Diagnosis of Keratoconus

Purpose: To diagnose keratoconus from healthy eyes, as well as suspected keratoconus. Methods: Certain parameters were extracted from Casia, Corvis, and Pentacam HR devices for 3 groups of healthy, with keratoconus, and suspected keratoconus. This study was performed on 340 eyes with keratoconus, 310 normal eyes, and 350 suspected keratoconus. The processing method involved the fusion of featur...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • International journal of ophthalmology

دوره 8 5  شماره 

صفحات  -

تاریخ انتشار 2015